Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1979-08-27
1981-08-04
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435228, 435822, 424274, 435 34, 2602452T, C12P 1718
Patent
active
042823226
ABSTRACT:
This invention relates to two new antibiotics, desacetyl 890A.sub.1 and desacetyl 890A.sub.3, active against both gram-positive and gram-negative bacteria, which are produced by treating 890A.sub.1 and 890A.sub.3, respectively, with an N-acetylthienamycin amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process whereby N-acetylated structures of the thienamycin class of antibiotics such as N-acetyl thienamycin can be enzymatically deacetylated.
REFERENCES:
patent: 3821081 (1974-06-01), Abe et al.
patent: 3930949 (1976-01-01), Kutzbach et al.
patent: 3945888 (1976-03-01), Takahashi et al.
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4229534 (1980-10-01), Kahan et al.
patent: 4235967 (1980-11-01), Cassidy et al.
Kahan Frederick M.
Kahan Jean S.
Mahon Frank M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Shapiro Lionel M.
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