Process for enhancing the solubility of poorly soluble drugs

Details Process for enhancing the solubility of poorly soluble drugs Process for enhancing the solubility of poorly soluble drugs

2008-02-25

2009-10-27

Francis, Faye (Department: 3725)

Solid material comminution or disintegration

Processes

With application of fluid or lubricant material

C241S023000, C241S029000

Reexamination Certificate

active

07607596

ABSTRACT:
The solubility/dissolution rate of a poorly soluble drug is enhanced by a process that utilizes a twin-screw extruder containing (i) a feed zone containing a first liquid and powder feed stations; (ii) a grinding/mixing zone containing a second liquid feed port located at an upstream portion of such zone; (iii) a granulation zone containing a second powder feed station located at an upstream portion of such zone and a third liquid feed port located at a downstream portion of such zone; and (iv) a wet milling zone.

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