Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1991-10-09
1993-03-02
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
427189, 424465, C07C 53134
Patent
active
051911140
ABSTRACT:
Direct compressible ibuprofen particles are formed by treating commercially available, dry ibuprofen with a hydrophilic solvent in one embodiment, a mixture of a hydrophilic solvent and one or more hydrophobic organic solvents in a second embodiment and one or more hydrophobic organic solvents in a third embodiment, to change at least the external crystalline shape of the ibuprofen from a flow-retarding shape to a free-flowing, easily compressible configuration. A typical hydrophilic solvent is water and among the hydrophobic solvents which may be used are acetone, methyl alcohol, ethyl alcohol, isopropyl and N-propyl alcohol. Direct compressible ibuprofen particles having superior flow characteristics may also be prepared by mixing commercially available, dry ibuprofen with micron size, amorphous silica gel in various formulations.
REFERENCES:
patent: 4476248 (1984-10-01), Jordon
patent: 4690834 (1987-09-01), Appelgren et al.
patent: 4904477 (1990-02-01), Ho et al.
patent: 4910023 (1990-03-01), Botzolakis
patent: 4911921 (1990-03-01), Denton et al.
patent: 4994604 (1991-02-01), Tung et al.
Harrison John M.
Killos Paul J.
Sage Pharmaceuticals, Inc.
LandOfFree
Process for enhancing the flow characteristics of ibuprofen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for enhancing the flow characteristics of ibuprofen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for enhancing the flow characteristics of ibuprofen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-127776