Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Reexamination Certificate
2001-04-30
2003-11-04
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
C424S400000, C424S441000, C424S442000, C424S484000, C424S489000, C426S074000
Reexamination Certificate
active
06641836
ABSTRACT:
BACKGROUND OF THE INVENTION
This invention relates to a dietary composition and method for enhancing immune response and improving the overall health of canines, and more particularly, to a dietary composition which includes an effective amount of garlic, which, when fed to canines, provides antioxidant, anticancer, and immunomodulatory benefits.
In recent years, the health effects of garlic for humans have become an area of active research with regard to the prevention and treatment of disease. Garlic may be provided in many forms; e.g., as a natural product in raw or cooked form, as a water or oil soluble extract, a powder, and as purified forms of the bioactive compounds.
Studies have shown that organosulfur compounds found in garlic have antioxidant properties. In addition, it has been found that garlic may also function as an anticancer agent. For example, the garlic compound S-allylmercaptocysteine has been found to reduce the growth of human prostate carcinoma LNCaP cells.
1
Garlic has also been found to reduce the incidence of chemical induced tumors in rats.
2
1
Pinto J T, Qiao C, Xing J, Rivlin R S, Protomastro M L, Weissler M L, Tao Y, Thaler H, Heston W D, “Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture”
Am J Clin Nutr
1997; 66:398-405.
2
Liu J, Lin R I, Milner J A, “Inhibition of 7, 12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by garlic powder”
Carcinogenesis
1992; 13:1847-1851.
It is also believed that the sulfur-containing components of garlic may contribute to immune modulating properties. For example, a garlic extract and a garlic protein fraction were found to increase the oxidative burst of a J744 mouse macrophage cell line and mouse peritoneal macrophages.
3
3
Lau B H, Yamasaki T, Gridley D S, “Garlic compounds modulate macrophage and T-lymphocyte functions”
Mol Biother
1991; 3:103-107.
However, few studies have been conducted to evaluate the effects of garlic on companion animals such as canines. Accordingly, there is still a need in the art for a method of utilizing the health benefits of garlic in a dietary composition for canines.
SUMMARY OF THE INVENTION
The present invention meets that need by providing a process for feeding dogs a diet containing an effective amount of garlic which has been found to provide enhanced immune response and improve the overall health of the animal. Preferably, the dog is fed a diet which includes garlic in an amount of from about 1 to 10 g/kg diet.
When a composition containing an effective amount of garlic is administered to dogs in a quantity and frequency appropriate for their nutritional needs, it has been found that the immune response is enhanced by increased lymphocyte blastogenesis.
Accordingly, it is a feature of the present invention to provide a process for enhancing immune response and improving the overall health of dogs by providing an effective amount of garlic in the diet of the animal. This, and other features and advantages of the present invention, will become apparent from the following detailed description and accompanying drawings.
REFERENCES:
patent: 4702914 (1987-10-01), Ryan
patent: 5141755 (1992-08-01), Weisman
patent: 5776524 (1998-07-01), Reinhart
patent: 5976549 (1999-11-01), Lewandowski
patent: 6007860 (1999-12-01), Erasmus et al.
patent: 6156355 (2000-12-01), Shields et al.
patent: 2 595 548 (1987-09-01), None
patent: 2 321 583 (1998-08-01), None
patent: 57192318 (1982-11-01), None
patent: WO 93 06749 (1993-04-01), None
patent: WO 99 48381 (1999-09-01), None
patent: WO 00 01399 (2000-01-01), None
L.W.V. Deboer et al: “Partial protection from platelet thrombi in canine coronaries” Federation Proceedings, vol. 46, No. 4, 1987, p. 1316.
Pinto, James T. et al.; “Effects of garlic thioallyl derivatives on growth, gluthathione concentration, and polyamine formation of human prostate carcinoma cells in culture” Am J Clin Nutr 1997; 66:398-405.
Liu, Jinzhou et al.; “Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by garlic powder” Carcinogenesis 1992; 13:1847-1851.
Lau, Benjamin H.S. et al.; “Garlic compounds modulate macrophage and T-lymphocyte functions” Mol Biother 1991; 3:103-107.
Boebel Katherine P.
Hayek Michael G.
Massimino Stefan Patrick
Evans Charesse
McDow-Dunham Kelly L.
Page Thurman K.
LandOfFree
Process for enhancing immune response in canines using a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for enhancing immune response in canines using a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for enhancing immune response in canines using a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3158347