Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1996-11-06
1998-07-07
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
4351723, 4352521, 536 71, C12P 1962, C12N 1500, C12N 120, C07H 1708
Patent
active
057767351
ABSTRACT:
The process of this invention is directed to isolating or otherwise obtaining an olefinic macrolide producing microorganism which microorganism does not contain epoxidase enzyme activity. This invention also relates to a process for preparing said olefinic macrolide by fermenting a mutant microorganism lacking epoxidase activity, designated rosX herein, which mutant is obtained from the wild-type microorganism. This invention also relates to a rosX mutant of Micromonospora rosaria, and to any microorganism having the identifying characteristics thereof, said mutant also designated ATCC 55709. This invention also relates to a process for preparing repromicin, the compound of formula (II), ##STR1## by mutating a wild-type microorganism capable of producing rosamicin to produce a mutant microorganism lacking epoxidase activity such that repromicin is produced by said mutant microorganism.
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patent: 3975372 (1976-08-01), Ganguly et al.
patent: 4357325 (1982-11-01), Ose et al.
Puar et al., Journal of Antibiotics, 43, 1497-1501, (1990).
Wagman et al., Journal of Antibiotics, 25, 641-646, (1972).
Fukagawa et al., Journal of Antibiotics, 37, 118-126, (1984).
Denoya Claudio D.
Hafner Edmund W.
McArthur Hamish A. I.
Benson Gregg C.
Brusca John S.
Degen Nancy
Pfizer Inc.
Richardson Peter C.
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