Process for determining the particle size distribution of an...

Details Process for determining the particle size distribution of an... Process for determining the particle size distribution of an...

2007-07-24

2007-07-24

Warden, Jill (Department: 1743)

Chemistry: analytical and immunological testing

Including sample preparation

C436S181000, C436S164000, C422S082050, C422S083000

Reexamination Certificate

active

10202572

ABSTRACT:
The measurement of the particle size distribution of an aerosol is of crucial importance in pharmaceutical development. A prerequisite for this is a valid method, e.g. the cascade impactor method described in the pharmacopoeias. It requires measurement of the active substance concentration in order to determine the particle size distribution. The invention provides a process which makes it possible to measure the size of aerosol droplets containing pharmaceutical substances which are unstable in the event of changes in the pH.

REFERENCES:
patent: 3809478 (1974-05-01), Talbot
patent: 5250186 (1993-10-01), Dollinger et al.
patent: 5957124 (1999-09-01), Lloyd et al.
patent: 6315984 (2001-11-01), Modi
patent: 6386015 (2002-05-01), Rader et al.
patent: 2003/0034032 (2003-02-01), Ziegler et al.
patent: 2340932 (2000-01-01), None
patent: WO 91/10123 (1991-07-01), None
Stein, Stephen W.; Size distribution measurements of metered dose inhalers using Andersen Mark II cascade impactors, International Journal of Pharmaceutics, p.D. 199, p. 43-52—XP-002224771.
Kippax, P., et al; Analysis of dry powders aerosols using laser diffraction British Pharmaceutical Conference 2001 Abstract Book, 121—XP002224772.
M. Dolovich, Measurement of Particle Size characteristics of Metered Dose Inhaler (MDI) Aerosols, Journal of Aerosol Medicine, Jul. 1991, pp. 251-263, 4(3).

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