Process for determining the concentration of benzodiazepines in

Details Process for determining the concentration of benzodiazepines in Process for determining the concentration of benzodiazepines in

1979-01-18

1981-07-28

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

422 61, 23230B, 424 15, 424 12, G01N 3348, A61K 4300, G01T 100

Patent

active

042809932

ABSTRACT:
A process for determining the concentration of benzodiazepines in a body liquid comprising the steps of contacting freeze-dried brain tissue with tritium labelled flunitrazepam to bond labelled flunitrazepam to receptor sites of the brain tissue, determining the concentration of labelled flunitrazepam of the brain tissue, incubating the brain tissue containing labelled flunitrazepam with a sample of body liquid containing benzodiazepine, the concentration of which is to be determined, to induce displacement of labelled flunitrazepam from said brain tissue, determining the concentration of labelled flunitrazepam bonded to the brain tissue after establishing equilibrium conditions and determining the concentration of benzodiazepine in the body liquid based on the change of concentration of labelled flunitrazepam induced by benzodiazepine contained in the sample.

REFERENCES:
patent: 3335295 (1967-08-01), Sternbach et al.
patent: 3336296 (1967-08-01), Bell et al.
patent: 3338886 (1967-08-01), Berger et al.
patent: 3546212 (1970-12-01), Feux et al.
patent: 4022878 (1977-05-01), Gross
patent: 4083948 (1978-04-01), Davis et al.
Peskov et al., J. Pharmactl. Exp. Ther., vol. 186, No. 1, Jul. 1973, pp. 167-172.

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