Process for determining the complement-dependent cytotoxicity me

Details Process for determining the complement-dependent cytotoxicity me Process for determining the complement-dependent cytotoxicity me

1980-03-31

1982-02-02

Wiseman, Thomas

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 8, 435291, 23230B, 424 8, 424 12, 422 52, C12Q 166, G01N 3354

Patent

active

043140262

ABSTRACT:
The present invention relates to a process for determining the complement-dependent cytotoxicity mediated by anti-HLA antibodies wherein the cytotoxicity is determined by measuring the loss of intracellular ATP after addition of complement to anti-HLA coated target cells. the invention also relates to an automatical device for ATP determination.

REFERENCES:
patent: 3359973 (1967-12-01), Hoffman
patent: 3520660 (1970-07-01), Webb
patent: 3728227 (1973-04-01), Elson et al.
patent: 3999948 (1976-12-01), Derndoerfer et al.
patent: 4104126 (1978-08-01), Young
Descamps, "Determination of Intracellular Adenosinetriphosphate for Detecting Anti-HLA Antibody Medicated Cytolysis, Introduction to a New Method for HLA Typing", Chem. Abstracts, vol. 92, No. 1, p. 294 (1980), Abs. No. 177041q.
Demetriou, et al., "An Enzymatic Method Permitting Early Determination of Histocompatibility in Mixed Lymphocyte Culture", Chem. Abstracts, vol. 90, No. 15, p. 469 (1979), Abs. No. 119497r.
Descamps, Ann. Immunol., (Institut Pasteur), vol. 130, (1979), pp. 595-600.

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