Process for determining concentration of an analyte in a sample

Details Process for determining concentration of an analyte in a sample Process for determining concentration of an analyte in a sample

1994-08-01

1996-06-18

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

356335, 356336, 422 73, 436536, 436538, 436805, G01N 33546

Patent

active

055277144

ABSTRACT:
Particle size distributions with greatly improved accuracy are prepared for diagnostic analysis using antigen/antibody reactions to concentrate sensitized insoluble carriers into non-aggregated and aggregated particles of known size. The analyte is analyzed by an electronic analyzer to determine the quantity and size distribution of concentrated non-aggregated and aggregated insoluble carriers resulting from the antigen/antibody reaction, as well as spurious particles that may be present in the analyte. The concentrated non-aggregated and aggregated insoluble carriers occur in known regions of the measured size distribution. The spurious particles exist throughout the size distribution. The distribution of spurious particles is determined in the regions where the desired particles are known to be absent. A complete distribution of spurious particles is constructed by interpolation using a cubic spline function. The initial measured size distribution is corrected by subtracting the interpolated spurious particle distribution from the initial size distribution.

REFERENCES:
patent: 4521521 (1985-06-01), Abbott et al.
patent: 4851329 (1989-07-01), Cohen et al.
patent: 4929079 (1990-05-01), Delfour et al.
MacDonald et al, Cytometry, Jul. 1982, 3(1), pp. 55-58 (Abstract).

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