Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-01
1997-02-18
Ketter, James S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9121, 435194, 536 243, 536 2433, C12Q 168, C12P 1934, C12N 912, C12N 1511
Patent
active
056040997
ABSTRACT:
Single or multiple nucleotide variations in nucleic acid sequence can be detected in nucleic acids by a process whereby the sample suspected of containing the relevant nucleic acid is repeatedly treated with primers, nucleotide triphosphates, and an agent for polymerization of the triphosphates and then denatured, in a process which amplifies the sequence containing the nucleotide variation if it is present. In one embodiment, the sample is spotted on a membrane and treated with a labeled sequence-specific oligonucleotide probe. Hybridization of the probe to the sample is detected by the label on the probe.
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Erlich Henry A.
Horn Glenn
Mullis Kary B.
Saiki Randall K.
Hoffmann-La Roche Inc.
Johnston George W.
Ketter James S.
Petry Douglas A.
Sias Stacey R.
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