Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-23
2006-05-23
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007930, C435S007940, C435S007950, C435S194000, C436S501000
Reexamination Certificate
active
07049080
ABSTRACT:
The present invention describes a process for detecting threonine or serine kinase activity in an immunoassay using a pre-phosphorylated substrate.
REFERENCES:
patent: 2003/0023990 (2003-01-01), Davis et al.
patent: 2003/0027236 (2003-02-01), Burke et al.
patent: WO 96/3642 (1996-11-01), None
patent: 9929894 (1999-06-01), None
Mosier et al., Immunoassay Protocol for Quantitation of Protein Kinase Activities, Methods in Enzymology, vol. 305, May 2000, pp. 410-416.
Lawler et al., “Synergistic activation of SAPK1/JNK1 by two MAP kinase kinasesin vitro”, Current Biology, vol. 8, 25.
Khokhlatchev, “Reconstruction of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria”, The Journal of Biological Chemistry, vol. 272, No.17.
Borgne et al., “Sequential Dephosphorylation of p. 34cdc2on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition”, The Journal of Biological Chemistry, vol. 271, No. 44.
Seethala, “A Fluorescense Polarization Competition Immunoassay for Tyrosine Kinases”, Analytical Biochemistry 255, 1998.
Fleming et al., “Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7”, Biochem. J. (2000) 352.
Wu et al., “Identificate of a High-Affinity Anti-Phosphoserine Antibody for the Development of a Homogeneous Flueorescence Polarization Assay of Protein Kinase C”, Jounral of Biomolecular Screening vol. 5, No. 1, 2000.
Khokhlatchev Andrei et al., “Reconstitution of Mitogen-Activated Protein Kinase Phosphorylation Cascades in Bacteria: Efficient Synthesis of Active Protein Kinase”,Journal of Biological Chemistry, vol. 272, No. 17, 1997, pp. 11057-11062.
Martin Humberto et al., “Regulatory Mechanisms for Modulation of Signaling Through the Cell Integrity S1t2-mediated Pathway inSaccharomyces cerevisiae”, Journal of Biological Chemistry, vol. 275, No. 2, Jan. 14, 2000 pp. 1511-1519.
Seethala Ramakrishina et al., “A Flurescence Polarization Competition Immunoassay for Tyrosine Kinases”,Analytical Biochemistry, Academic Press, San Diego, CA., vol. 255, Jan. 15, 1998, pp. 257-262.
Wu Jinzi J. et al., “Identification of a High-Affinity Anti-Phosphoserine Antibody for the Development of a Homogeneous Fluorescence Polarization Assay of Protein Kinase C.”,Journal of Biomolecular Screening, vol. 5, No. 1, Feb. 2000, pp. 23-30.
Lawler Sean et al., “Synergistic Activation of SAPK1/NJK1 by TWo MAP Kinase Kinases in Vitro”,Current Biologvol. 8, No. 25, Dec. 17, 1998, pp. 1387-1390.
Hoffmann Ralf et al.; “Phosphorylation of the C-Terminal Sites of Human p53 Reduces Non-Sequence-Specific DNA Binding as Modeled with Synthetic Peptides”,Biochemistry, vol. 37, No. 39, pp. 13755-13764.
Barancik Miroslav et al., “Okadaic Acid and Anisomycin are Protective and Stimulate the SAPK/JNK Pathway”,Journal of Cardiovascular Pharmacology, vol. 34, No. 2, Aug. 1999, pp. 182-190.
Fleming Yvonne et al., “Synergistic Activation of Stress-Activated Protein Kinase 1/c-June N-Terminal Kinase (SAPK1/JNK) Isoforms by Mitogen-Activated Protein Kinase Kinase 4 (MKK4) and MKK7”,Biochemical Journal, vol. 352, No. 1, Nov. 15, 2000, pp. 145-154.
Benson Neil
Bethell Richard
Boyd Helen
Greengrass Pam
Kinloch Ross
Baker & Botts LLP
Counts Gary W.
Le Long V.
LandOfFree
Process for detecting serine/threonine kinase activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for detecting serine/threonine kinase activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for detecting serine/threonine kinase activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3525594