Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1994-06-27
1998-06-09
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 92, 424 98, 4351723, 800 2, A61K 4900, C12N 1506
Patent
active
057629080
ABSTRACT:
A process is described for the screening of an agent to determine its effect on the frequency of genome rearrangement in mammals. In particular, mice harboring a p.sup.un mutation are exposed to an agent of interest and the frequency of genome rearrangement relative to that observed in an unexposed mouse is determined. The relative frequency of rearrangement represents a measure of the effect of the agent on the host animal.
REFERENCES:
Favor et al., 1987, Genetic Research and Recombination 50:219-223.
Brilliant et al., Apr. 1991, Science 252:566-569.
Burkhart et al., Apr. 1991, "Transgenic Mice in Developmental Biology and Toxicology", National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, Apr. 1-2, p. 21.
Short, "Transgenic Mice in Developmental Biology and Toxicology", National Institute of Environmental Health Science, Research Triangle Park, North Carolina, Apr. 1-2, 1991, p. 22.
Gossen et al., "Transgenic Mice in Developmental Biology and Toxicology", National Institute of Environmental Health Science, Research Triangle Park, North Carolina, Apr. 1-2, 1991, p. 23.
Myhr, "Transgenic Mice in Developmental Biology and Toxicology", National Institute of Environmental Health Science, Research Triangle Park, North Carolina,Apr. 1-2, 1991, p. 24.
Greenwald Howard J.
Harvard College, President and Fellows
Stanton Brian R.
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