Process for detecting cancer and for monitoring the effectivenes

Details Process for detecting cancer and for monitoring the effectivenes Process for detecting cancer and for monitoring the effectivenes

1987-11-09

1990-08-07

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436501, 436536, 436548, 436 64, 436813, 530350, 530380, 935110, G01N 3353, G01N 33536, C07K 1500, C12N 1500

Patent

active

049467743

ABSTRACT:
A process for detecting cancer in a human patient is provided wherein a blood serum is recovered from the patient and is reacted with a monoclonal antibody comprising anti-haptoglobin variant under conditions to effect an immunoreaction when an immunosuppressive factor having a molecular weight of about 50K Daltons is present in the serum. The presence of immunosuppressive factor at concentration levels substantially exceeding normal concentration levels indicates the existence of immunoincompetence due to widely spread cancer. The effectiveness of cancer therapy is monitored by monitoring the change in levels of the immunosuppressive haptoglobin variant factor in the serum from the patient being treated.

REFERENCES:
patent: 4537712 (1985-08-01), Oh
patent: 4720385 (1988-01-01), Lembach
Oh et al., Cancer Res., Oct. 1, 1987, vol. 47(19), pp. 5120-5126.
Weiss et al., Cancer Detect. Prev., 1981, vol. 4(1-4), pp. 211-217.
Israel et al., Biomedicine, Oct. 1978, vol. 28(5), pp. 292-297.
Katnik et al., Journal of Immunological Methods, vol. 102, 1987, pp. 279-282.
Wolf et al., Am. J. Surg (U.S.A.), vol. 138/4, 1979, pp. 489-500.
Israel et al., Inserm, vol. 97, 1980, pp. 53-63.
Wiedermann et al., Neoplasma, vol. 26, 1979, pp. 315-324.
Akima et al., Gan to Kagaku Ryoho (Cancer and Chemotherapy), vol. 12(6), 1985, pp. 1278-1285.

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