Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1988-01-21
1989-06-20
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544231, 544360, C07D24108
Patent
active
048410535
ABSTRACT:
Certain polysubstituted piperazinones (PSP) having two or three methylene groups linking the N.sup.1 atom of the ring to the N atom of a terminal amine group, are found to be peculiarly prone to decomposition when subjected to elevated temperature after being contacted with water, and sensitive to the amount of base used in the base-induced ketoform reaction which generates the PSP represented by the structure ##STR1## These PSP are therefore produced by a modification of the ketoform reaction under essentially anhydrous conditions, using enough ketone to dissolve the PSP formed and a molar ratio of solid alkali metal hydroxide/diamine reactant in the range from at least 5 but less than 7. The PSP produced is recovered as a solution in the ketone, without contacting the PSP with water. The PSP product obtained after the ketone is distilled, is essentially pure.
REFERENCES:
patent: 4167512 (1979-09-01), Lai
patent: 4190751 (1980-02-01), Lai et al.
patent: 4466915 (1984-08-01), Lai
patent: 4780495 (1988-10-01), Lai et al.
Jacobs Charles P.
Kovach Ronald M.
Lai John T.
Son Pyong-Nae
Lobo Alfred D.
Raymond Richard L.
Shust Nestor W.
The B. F. Goodrich Company
Turnipseed James H.
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