Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-06-01
1997-07-08
Cano, Milton
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 29, 4352351, 435948, 210 87, 210651, C12Q 170
Patent
active
056459840
ABSTRACT:
To deplete viruses in organic material, the material to be purified is conveyed through an ultrafilter or an ultrafiltration unit the depletion rate of which is previously determined. The filter or filtration unit is charged with viruses of the family Leviviridae and the viral count is determined before and after filtration and used to derive the depletion rate. The virus depletion can be monitored during the process by following the depletion of a marker.
REFERENCES:
Bechtel, et al. Virus Removal or Inactivation in Hemoglobin Solutions by Ultrafiltration or Detergent/Solvent Treatment, Biomat., Art. Cells, Art. Org. 16(1-3):123-128 (1988). (Exhibit C).
Dulbecco, R. and Ginsberg, H.S., Virology, 2nd ed., J.B. Lippincott Co., p. 5 (1986). (Exhibit D).
Hamamoto, J. et al., A Novel Method for Removal of Human Immunodeficiency Virus: Filtration with Porous Polymeric Membranes, Vox Sang 56:230-236 (1989). (Exhibit E).
Pschyrembel W., Klinisches Worterbuch, Walter de Bruyter, (1982), p. 926 [in German] (Exhibit F).
Zottola et al. J Dairy Science 70:2013-2021 1987.
Cooper "The Tools of Biochemistry" John Wiley & Sons, New York (1977) pp. 206-208.
Knolle et al Virology vol 123: pp. 271-273 (1964).
Applied and Environmental Microbiology, vol. 52(3), Sep. 1986, Traub et al., "Method for Determining Virus Inactivation During Sludge Treatment Processes", pp. 498-503.
Chemical Abstracts, vol. 117, No. 21, Nov. 23, 1992, Becker et al., "Method for Control of Rate of Removal of Pyrogenic Substances, Especially Viruses, From Organic Materials.", Abstract No. 117:208472x, DE 4,126,034.
Cano Milton
Sanorell Pharma GmbH & Co. KG
White John P.
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