Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2003-10-06
2008-10-14
Paras, Jr., Peter (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S093200
Reexamination Certificate
active
07435723
ABSTRACT:
Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.
REFERENCES:
patent: 5521291 (1996-05-01), Curiel
patent: 5580859 (1996-12-01), Felgner
patent: 5583020 (1996-12-01), Sullivan
patent: 5698531 (1997-12-01), Nabel et al.
patent: 5922687 (1999-07-01), Mann
patent: 2004/0023850 (2004-02-01), Wolff et al.
patent: 2005/0153451 (2005-07-01), Wolff et al.
Parekh-Olmedo H, Gene therapy progress and prospects: targeted gene repair, 2005, Gene Therapy, vol. 12, pp. 639-646.
Verma IM, Gene Therapy: Twenty-first century medicine, 2005, Annu. Rev. Biochem. vol. 74, pp. 711-738.
Concalves M, A concise peer into the background, initial thoughts, and practices of human gene therapy, 2005, BioEssays, vol. 27, pp. 506-517.
Zhu N, Systemic gene expression after intravenous DNA delivery into adult mice, 1993, Science, vol. 261, pp. 209-211.
Acsadi G et al. “Direct gene transfer and expression into rat heart in vivo.” The New Biologist 1991 vol. 3, No. 1, pp. 71-81.
Barron LG et al., “Cationic Lipids Are Essential For Gene Delivery Mediated By Intravenous Administration of Lipoplexes.” Gene Therapy 1999 vol. 6 pp. 1179-1183.
Bohm W et al., “Routes of Plasmid DNA Vaccination That Prime Murine Humoral and Cellular Immune Responses.” Vaccine 1998; vol. 16, No. 9/10; pp. 949-954.
Budker V et al., “Naked DNA Delivered Intraportally Expresses Efficiently in Hepatocytes.” Gene Therapy 1996; vol. 3 pp. 593-598.
Budker V et al., “The Efficient Expression of Intravascularly Delivered DNA in Rat Muscle.” Gene Therapy 1998 vol. 5 pp. 272-276.
Chapman G et al. “Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter,” Circ. Res; 1992 vol. 71 pp. 27-33.
Coll JL et al. “In Vivo Delivery to Tumors of DNA Complexed With Linear Polyethylenimine.” Human Gene Therapy 1999 vol. 10 pp. 1659-1666.
Goula, D. Et al., “Polyethylenimine-Based Intravenous Delivery of Transgene to Mouse Lung.” Gene Therapy 1998/5; pp. 1291-1295.
Greelish JP et al. “Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector.” Nature; 1999 vol. 5 No. 4 pp. 439-443.
Hickman MA et al. “Gene expression following direct injection of DNA into liver,” Hum Gene Ther; 1994 vol. 5, No. 12 pp. 1477-1483.
Hickman MA et al. “Gene expression following direct injection of DNA into liver,” Hum Gene Ther; 1994 vol. 5, No. 12 pp. 1477-1483.
Kawabata, K. Et al., “The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake.” Pharmaceutical Research 1995; vol. 12, No. 6; pp. 825-830.
Liu F et al. “Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA,” Gene Ther; 1999 vol. 6 pp. 1258-1266.
Liu Y et al. “Cationic Liposome-Mediated Intravenous Gene Delivery.” J Biol Chem 1995 vol. 270 No. 42; pp. 24864-24870.
Malone RW et al. “Dexamethasone enhancement of gene expression after direct hepatic DNA injection,” J Biol Chem; 1994 vol. 269, No. 47 pp. 29903-29907.
McLean JW et al., “Organ-Specific Endothelial Cell Uptake of Cationic Liposome-DNA Complexes in Mice.” The American Physiological Society 1997; pp. H387-H404.
Meyer KB et al. “Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics,” Gene Ther; 1995 vol. 2, No. 7 pp. 450-460.
Milas M et al. “Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system,” Clin Cancer Res; 1997 vol. 3 No. 12 Pt. 1, pp. 2197-203.
Riessen R et al. “Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon,” Hum Gene Ther; 1993 vol. 4, No. 6 pp. 749-758.
Sikes ML et al. “In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection,” Hum Gene Ther; 1994 vol. 5, No. 7 pp. 837-844.
Song YK et al., “Enhanced Gene Expression in Mouse Lung by Prolonging the Retention Time of Intravenously Injected Plasmid DNA.” Gene Therapy 1998; 5; pp. 1531-1537.
Soriano P et al. “Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene,” PNAS; 1983 vol. 80 pp. 7128-7131.
Vile RG et al. “In vitro and in vivo targeting of gene expression to melanoma cells,” Cancer Res; 1993 vol. 53 pp. 962-967.
Von Der Leyen H et al., “A Pressure-Mediatated Nonviral Method For Efficient Arterial Gene and Oligonucleotide Transfer.” Human Gene Therapy 1999 vol. 10 pp. 2355-2364.
Wolff JA et al. “Direct gene transfer into mouse muscle in vivo.” Science 1990 vol. 247 pp. 1465-1468.
Zhang et al. “Efficient expression of naked dna delivered intraarterially to limb muscles of nonhuman primates,” Human Gene Therapy 2001 vol. 12 No. 4 pp. 427-438.
Zhang G et al. “High Levels of Foreign Gene Expression in Hepatocytes after Tail Vein Injections of Naked Plasmid DNA,” Human Gene Therapy 1999; vol. 10 pp. 1735-1737.
Zhang G et al., “Expression of Naked Plasmid DNA Injected Into the Afferent and Efferent Vessels of Rodent and Dog Livers.” Human Gene Therapy 1997; vol. 8 pp. 1763-1772.
Zhu N et al., “Systemic Gene Expression After Intravenous DNA Delivery Into Adult Mice.” Science 1993; vol. 261 pp. 209-211.
Budker Vladimir G.
Hagstrom James E.
Hegge Julia
Noble Mark
Ekena Kirk
Johnson Mark K.
Mirus Bio Corporation
Montanari David A.
Paras, Jr. Peter
LandOfFree
Process for delivery of polynucleotides to the prostate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for delivery of polynucleotides to the prostate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for delivery of polynucleotides to the prostate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4019409