Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2002-11-01
2004-06-08
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06747161
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a process for producing an optically active azetidine-2-carboxylic acid, which is of value as a production intermediate of pharmaceuticals or the like, through the cyclization of an optically active 4-amino-2-halogenobutyric acid.
BACKGROUND ART
The following processes are known for the production of azetidine-2-carboxylic acid through utilization of the cyclization reaction of a 4-amino-2-halogenobutyric acid.
(1) A process which comprises subjecting hydrochloric acid-nitrous acid to act on (S)-2,4-diaminobutyric acid to give (S)-4-amino-2-chlorobutyric acid and, then, heating it in an aqueous solution of barium hydroxide to give (R)-azetidine-2-carboxylic acid (Biochemical Journal, 64, 323 (1956)).
(2) A process which comprises subjecting dimethyl sulfate to act on pyrrolidin-2-one to give methoxyimine, brominating it with N-bromosuccinimide, hydrolyzing the same to DL-4-amino-2-bromobutyric acid, and heat-treating it in an aqueous solution of barium hydroxide or sodium hydroxide to give DL-azetidine-2-carboxylic acid (Agricultural and Biological Chemistry, 37, 649 (1973).
However, the above processes have the following drawbacks.
In process (1) wherein the cyclization reaction is conducted under heating at a high temperature in an aqueous solution of barium hydroxide, the optically active compound undergoes racemization to drastically reduce the optical purity of the product. Of the product with such a drastically reduced optical purity, one of the enantiomers is generally unwanted and an optical resolution or the like procedure is required for improving the optical purity. Moreover, the unwanted enantiomer so separated has to be discarded unless a profitable racemization method is available, with the result that the process is not economical and does not lend itself well to commercial production.
In process (2), the product azetidine-2-carboxylic acid is a racemic compound and the resolution of this racemic compound is necessary for obtaining the optically active compound. Moreover, after resolution the unwanted enantiomer has to be discarded unless a profitable racemization method is available so that this process is not economical and does not lend itself well to commercial production.
SUMMARY OF THE INVENTION
In view of the above state of the art, the present invention has its object to provide an efficient, economical and commercially profitable process for producing an optically active azetidine-2-carboxylic acid.
The inventors of the present invention did much research for overcoming the above-mentioned disadvantages and have ultimately developed the present invention.
The present invention, therefore, is directed to a process for producing optically active azetidine-2-carboxylic acid of the general formula (2):
(wherein * denotes an asymmetric carbon atom) which comprises cyclizing an optically active 4-amino-2-halogenobutyric acid represented by the general formula (1):
(wherein X represents a halogen atom; * denotes an asymmetric carbon atom) in the presence of an oxide of an alkaline earth metal, a hydroxide of an alkaline earth metal excepting barium, or an organic amine. In accordance with the present invention, there is provided a process for producing optically active azetidine-2-carboxylic acid in high optical yield.
The present invention is now described in detail.
DISCLOSURE OF INVENTION
The starting material of the invention, namely an optically active 4-amino-2-halogenobutyric acid, may be whichever of the pure (R)-compound and the pure (S)-compound or a mixture of these compounds containing either enantiomer in excess but for the production of optically active azetidine-2-carboxylic acid, the material of high optical purity is, of course, preferred. Moreover, the halogen atom of said optically active 4-amino-2-halogenobutyric acid may be a fluorine, a chlorine, a bromine or an iodine atom but is preferably a chlorine or a bromine atom.
As such an optically active 4-amino-2-halogenobutyric acid, (S)-4-amino-2-chlorobutyric acid, for instance, can be obtained from (S)-2,4-diaminobutyric acid by the process described in Biochemical Journal, 64, 323 (1956). Moreover, by the process described in JPA Hei-11-169620, an (R)-4-amino-2-halogenobutyric acid ester can be hydrolyzed in an aqueous solution of a mineral acid to give a hydrolyzate solution containing an (R)-4-amino-2-halogenobutyric acid. This hydrolyzate solution may be neutralized with an alkali metal base, for instance, and directly submitted to the cyclization reaction or the neutralized solution may further be purified by ion exchange column chromatography to isolate the optically active (R)-4-amino-2-halogenobutyric acid.
The optically active 4-amino-2-halogenobutyric acid of general formula (1), thus obtained, can be cyclized in the presence of a base, such as an oxide of an alkaline earth metal, a hydroxide of an alkaline earth metal excepting barium, or an organic amine to produce optically active azetidine-2-carboxylic acid of general formula (2) in good optical yield.
The oxide of an alkaline earth metal which can be used in the cyclization reaction includes magnesium oxide, calcium oxide, barium oxide, etc., with magnesium oxide being particularly preferred. The hydroxide of an alkaline earth metal includes magnesium hydroxide, calcium hydroxide, etc., although magnesium hydroxide is particularly preferred.
As the organic amine, a secondary amine or a tertiary amine can be used with advantage. Among preferred examples are secondary alkylamines such as dimethylamine, diethylamine, dipropylamine, diisopropylamine, dibutylamine, diisobutylamine, di-sec-butylamine, di-tert-butylamine, dipentylamine, dihexylamine, diheptylamine, dioctylamine, dicyclohexylamine, etc.; secondary cycloalkylamines such as piperidine, piperazine, 2,2,6,6-tetramethylpiperidine, etc.; secondary arylamines such as diphenylamine, ditolylamine, etc.; secondary arylalkylamines such as dibenzylamine etc.; tertiary alkylamines such as trimethylamine, triethylamine, tripropylamine, triisopropylamine, tributylamine, triisobutylamine, diisopropylethylamine, diisobutylmethylamine, N,N-diethyl-tert-octylamine, etc.; tertiary cycloalkylamines such as 4-(dimethylamino)-1,2,2,6,6-pentamethylpiperidine etc.; tertiary arylamines such as triphenylamine, tritolylamine, etc.; tertiary arylalkylamines such as tribenzylamine etc.; polycyclic tertiary cycloamines such as 1,8-diazabicylo[4.5.0]undecene, 1,5-diazabicyclo[4.3.0]nonene, 1,4-diazabicyclo[2.2.2]octane, etc.; and tertiary aminealcohols such as N,N-dimethylethanolamine, N,N-diethylethanolamine, N,N-dipropylethanolamine, etc., although diisopropylamine, 2,2,6,6-tetramethylpiperidine, triethylamine, diisopropylethylamine, 1,8-diazabicyclo[4.5.0]undecene, and N,N-dimethylethanolamine are particularly preferred.
The level of use of said base is not particularly restricted but the cyclization reaction can be carried out generally in the presence of 1 to 30 molar equivalents of the base relative to the optically active 4-amino-2-halogenobutyric acid (1). The generally preferred level is 1 to 10 molar equivalents.
For the above cyclization reaction, a solvent is generally employed. This solvent is preferably water or a mixture of water and a water-soluble organic solvent which is freely miscible with water. The water-soluble organic solvent mentioned just above includes methanol, ethanol, isopropyl alcohol, tert-butyl alcohol, acetone, acetonitrile, N,N-dimethylformamide and N,N-dimethylacetamide, to mention just a few examples. The organic solvent can be used in a proportion of 1 to 100 volume %, preferably 1 to 50 volume %, relative to water.
The concentration of the optically active 4-amino-2-halogenobutyric acid (1) in the cyclization reaction system is generally 0.5 to 50 weight %, preferably 1 to 30 weight %.
The cyclization reaction temperature varies with different types of base used but is usually within the range of the freezing point to the boiling point of the reaction solvent, namely w
Honda Tatsuya
Nagashima Nobuo
Saka Yasuhiro
Kaneka Corporation
McKane Joseph K.
Shiao Robert
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