Process for crystallizing L-.alpha.-aspartyl-L-phenylalanine met

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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C07C22400

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057446326

ABSTRACT:
A crystalline L-.alpha.-aspartyl-L-phenylalanine methyl ester product and the process for obtaining the same are disclosed. This product is obtained by adjusting the initial concentration of L-.alpha.-aspartyl-L-phenylalanine methyl ester in an aqueous solution so that the amount of precipitated solid, formed after cooling said solution, is about 10 grams or more of precipitate per liter of solvent. The solution is then cooled through conductive heat transfer, without causing forced flow, to obtain a sherbet-like pseudo solid phase.

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Johnstone et al, Pilot Plants, Models and Scale-Up Methods In Chemical Engineering, (1957) p. 1, McGraw-Hill Book Co., Inc.
"Industrial Crystallization 78", Proceedings of the 7th Symposium on Industrial Crystallization, Warsaw, Poland, 25-27 Sep., 1978.
Delft University of Technology, The Netherlands, North-Holland Publishing Company--Amsterdam, New York (1979), pp. 405-414.

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