Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1991-06-18
1992-03-17
Gray, Bruce
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C07C22400
Patent
active
050970607
ABSTRACT:
A process for crystallizing L-alpha-aspartyl-L-phenylalanine methyl ester from its aqueous solution by cooling, which comprises adjusting the initial concentration of the ester so that the amount of a precipitated solid phase to be formed after cooling becomes about 10 grams or more per liter of the solvent, cooling the solution through conductive heat transfer through a cooled surface to form an apparently sherbet-like pseudosolid phase without causing forced flow by mechanical stirring or the like, and optionally further cooling the system after formation of the pseudosolid phase, is disclosed along with various apparatuses which may be used to carry out the invention.
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Kawasaki Haruo
Kishimoto Shin-ichi
Nakamura Masao
Naruse Masayoshi
Oura Harutoshi
Ajinomoto Company Incorporated
Gray Bruce
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