Process for crystallization of Ramipril and preparation of a...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07732620

ABSTRACT:
The present invention relates to a novel method for obtaining (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydro cyclopenta[b]pyrrole-2-carboxylic acid, viz. Ramipril(I) in high optical purity, free of other stereoisomers, and in high bulk density. The present invention also relates to a novel hydrated form of Ramipril(I) and a process for preparation thereof.

REFERENCES:
patent: 4587258 (1986-05-01), Gold et al.
patent: 5061722 (1991-10-01), Teetz et al.
patent: 6407262 (2002-06-01), Wang et al.
patent: 6541635 (2003-04-01), Tien et al.
patent: WO 2004/064809 (2004-08-01), None

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