Process for crystalline sodium cefamandole

Details Process for crystalline sodium cefamandole Process for crystalline sodium cefamandole

1978-06-05

1979-09-18

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50136

Patent

active

041683765

ABSTRACT:
A suspension of substantially pure sodium 7-(D-.alpha.-formyloxy-.alpha.-phenylacetamido)-3-(1-methyl-1H-tetrazol-5- ylthiomethyl)-3-cephem-4-carboxylate in methyl alcohol containing about 2% water on treatment with a methyl alcohol solution of sodium hydroxide is converted to a crystalline suspension of sodium 7-(D-.alpha.-hydroxy-.alpha.-phenylacetamido)-3-(1-methyl-1H-tetrazol-5-yl thiomethyl)-3-cephem-4-carboxylate in yields of about 65 to 70%.

REFERENCES:
patent: 3641021 (1972-02-01), Ryan
patent: 4006138 (1977-02-01), Yang
patent: 4054738 (1977-10-01), Yang
Indelicato, et al., Jour. Pharm. Sciences, G5 No. 8 (1976) pp. 1175-1178.

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