Process for creating molecular diversity and novel protease inhi

Details Process for creating molecular diversity and novel protease inhi Process for creating molecular diversity and novel protease inhi

1995-05-31

1999-03-02

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436528, 549388, 549392, G01N 33543, C07D31182

Patent

active

058770305

ABSTRACT:
Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.

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