Process for creating a skin substitute and the resulting skin su

Details Process for creating a skin substitute and the resulting skin su Process for creating a skin substitute and the resulting skin su

1995-06-06

1997-06-17

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435378, 435 701, 435 11, 435395, 435347, 623 15, 606132, 602 42, 602 43, 602 44, 602 45, 602 46, 424 7806, 424574, C12N 506, A61F 210

Patent

active

056396546

ABSTRACT:
The invention concerns a process for obtaining a skin substitute and the skin substitute itself. According to this process, a dermis substitute is prepared by mixing contractile cells, a nutritive medium, and collagen, in order to form a contracting gel; this dermis substitute is used as a substrate for an epidermis substitute obtained by culturing, using keratinocytes from an animal or human skin sample. According to the invention, the substrate is implanted with at least one section of a hair follicle retaining at least partially its cellular sheath, this section being implanted perpendicularly to the free surface of the substrate.

REFERENCES:
patent: 4485096 (1984-11-01), Bell
patent: 4604346 (1986-08-01), Bell
Limat et al, J. Invest. Dermatol., 87, 1986 pp. 485-488.
Vermorken, A. J. M. 1985 Atla 13, 8-37.

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