Process for coupling biological substances by covalent bonds

Details Process for coupling biological substances by covalent bonds Process for coupling biological substances by covalent bonds

1983-12-15

1986-06-03

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 6, 435 7, 435174, 435178, 435188, 435 21, 435810, 436512, 436518, 436520, 436522, 436536, 436543, 436547, 260112B, 536 11, 536 22, C12Q 128, C12N 1110, C12N 1100, C12N 1116

Patent

active

045929980

ABSTRACT:
This process involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. Said process making it possible for example to couple antibodies to enzymes for determining or detecting said antibodies. The process can be used for the determination of antitetanic antibodies in human serum.

REFERENCES:
patent: 3322634 (1967-05-01), Fulthorpe
patent: 4193982 (1980-03-01), Avrameas
Archives of Biochemistry and Biophysics 134 (1969), 515-523, Morrison et al.
Immunochemistry, 1974, vol. 11, pp. 261-269, Lemieux et al.
Biochimica et Biophysica Acta, 386 (1975) pp. 196-202, Brandt et al.
Immunochemistry, 1977, vol. 14, pp. 767-774, Ternynck et al.
Ann. Immunol (Inst. Pasteur), 1976, 127 C, 197-208, Ternynck et al.
EMBO Journal, vol. 2, No. 10, pp. 1655-1663, 1983, Louvard et al.
Joel W. Goodman, PhD, & An-Chuan Wang, PhD, "Basic & Clinical Immunology", Second Edition, pp. 23-24, Immunoglobulins: Structure & Diversity, Lange Medical Publications, Los Altos, Calif.

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