Process for coupling biological substances by covalent bonds

Details Process for coupling biological substances by covalent bonds Process for coupling biological substances by covalent bonds

1976-12-01

1980-03-18

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

23230B, 260112R, 260112B, 260121, 424 8, 424 11, 424 13, 424177, 435174, A61K 3700, A61K 3900, C07G 700, G01N 3100

Patent

active

041939824

ABSTRACT:
A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to couple antibodies to enzymes for determining or detecting said antibodies.
The process can be used for the determination of antitetanic antibodies in human serum.

REFERENCES:
patent: 3322634 (1967-05-01), Fulthorpe
Lemieux, Immunochem, vol. 11, 1974 pp. 261-269.
Morrison, Arch. Biochem. & Biophys., vol. 134, 1969 pp. 515-523.
Brandt, Biochim. & Biophys. Acta, vol. 386, 1975 pp. 196-202.

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