Process for converting [R(-)-2(3-benzoylphenyl)-propionic acid t

Details Process for converting [R(-)-2(3-benzoylphenyl)-propionic acid t Process for converting [R(-)-2(3-benzoylphenyl)-propionic acid t

1994-03-16

1995-06-20

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 562460, 562494, C07B 5700

Patent

active

054262151

ABSTRACT:
Process for transforming (benzoyl-3-phenyl)-2-propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the crystallization mother liquor of a (benzoyl-3-phenyl)-2-propionic-S(+) acid salt.

REFERENCES:
patent: 4209638 (1980-06-01), Nicholson et al.
patent: 4983765 (1991-01-01), Lukas et al.
patent: 5162576 (1992-11-01), Manimaran et al.

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