Process for converting preproinsulin analogs into insulins

Details Process for converting preproinsulin analogs into insulins Process for converting preproinsulin analogs into insulins

1984-10-12

1987-01-27

Waddell, Frederick E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530305, C07K 740

Patent

active

046393331

ABSTRACT:
The invention relates to a process for the preparation of insulins from analogs of preproinsulins, which comprises reacting preproinsulin analogs, at a pH below the isoelectric point of the insulins in the presence of trypsin or a trypsin-like endopeptidase, with an ester of natural amino acids or their derivatives and then cleaving off the ester group and other protective groups which may optionally be present.

REFERENCES:
Roberts and Caserio, Basic Principles of Organic Chemistry, pp. 715-716.
Lehninger, Biochemistry, pp. 158-159.

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