Process for converting penicillin sulfoxides to the correspondin

Details Process for converting penicillin sulfoxides to the correspondin Process for converting penicillin sulfoxides to the correspondin

1976-01-02

1977-09-27

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 2602391, C07D50110

Patent

active

040511332

ABSTRACT:
Conversion of penicillin sulfoxides to the corresponding 3-desacetoxycelphalosporins are carried out in high yield by heating, e.g. 80.degree.-130.degree. C, a solvent solution of the penicillin in the presence of a complex formed by a phosphite or phosphine amide with the salt of a strong acid and a nitrogenous base, e.g. alpha-picoline hydrobromide.
One preferred amide is 2-piperidino-1,3,2-dioxaphospolane.

REFERENCES:
patent: 3852295 (1974-12-01), Graham et al.
patent: 3935198 (1976-01-01), Murakami et al.
patent: 3936447 (1976-02-01), Petersen et al.

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