Process for converting optically active l-N-(2-amino-2-phenethyl

Details Process for converting optically active l-N-(2-amino-2-phenethyl Process for converting optically active l-N-(2-amino-2-phenethyl

1979-01-08

1982-07-13

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

2605711, 548351, 564220, 564372, C07C 2000

Patent

active

043396038

ABSTRACT:
There is provided a process for racemizing an undesirable, optically active compound for conversion to levamisole, namely, l-N-(2-amino-2-phenethyl)-2-methoxyethylamine, by converting the latter to optically active l-(2-methoxyethyl)-4-phenyl-2-imidazolidone, which is next converted to the corresponding optically inactive imidazolidone derivative, which derivative is hydrolyzed to the optically inactive racemate, dl-N-(2-amino-2-phenethyl)-2-methoxyethylamine. The latter can be resolved to obtain the d and l components of the racemate, the d component being utilized directly in levamisole synthesis and the l component being again subjected to the above procedure.

REFERENCES:
patent: 2514380 (1950-07-01), Duschinsky
patent: 3184460 (1965-05-01), Akkerman et al.
patent: 3845070 (1974-10-01), McMenim
patent: 3923808 (1975-12-01), Gelder et al.

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