Process for controlling intracellular glycosylation of proteins

Details Process for controlling intracellular glycosylation of proteins Process for controlling intracellular glycosylation of proteins

1988-12-21

1991-09-10

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4351723, 4352401, 435254, 935 50, 935 60, 536 27, C12N 1500, C12N 1556, C12N 1579

Patent

active

050473352

ABSTRACT:
A process for controlling the glycosylation of protein in a cell wherein the cell is genetically engineered to produce one or more enzymes which provide internal control of the cell's glycosylation mechanism. A Chinese hamster ovary (CHO) cell line is genetically engineered to produce a sialyltransferase. This supplemental sialyltransferase modifies the CHO glycosylation machinery to produce glycoproteins having carbohydrate structures which more closely resemble naturally occurring human glycoproteins.

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