Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-12-31
1987-08-25
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514275, A61K 31505
Patent
active
046893288
ABSTRACT:
A process for controlling hyperlipidemia in mammals is disclosed. In this process a mammal suffering from hyperlipidemia is treated with a hyperlipidemia controlling effective amount of a compound having the structural formula ##STR1## wherein R.sup.1 is mercapto, amino, hydroxy or C.sub.1 -C.sub.4 alkylthio; R.sup.2 is amino, hydroxy or mercapto; and R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.7 -C.sub.9 alkoxyphenyl or C.sub.7 -C.sub.9 aralkyl.
In another aspect of the present invention a pharmaceutical composition comprising the above compound in combination with a pharmaceutically acceptable carrier therefor is provided.
REFERENCES:
Journal of Pharmaceutical Sciences, vol. 73, No. 12, Dec. 1984; Hall et al.
J. Med. Chem., vol. 10, 248 and 290 (1967), Borodkin et al.
J. Amer. Chem. Soc., vol. 43, 19 (1910), Wheeler et al.
Cocolas George H.
Hall Iris H.
Lipovsky Joseph A.
Research Corporation
Schenkman Leonard
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