Process for controlling crystal structure of risedronate

Details Process for controlling crystal structure of risedronate Process for controlling crystal structure of risedronate

2006-02-21

2006-02-21

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S277000

Reexamination Certificate

active

07002014

ABSTRACT:
The present invention relates to a process for controlling the crystal form of 3-pyridyl-1-hydroxy-ethylidene-1,1-bisphosphonic acid salt (Risedronate). The process employs a pH adjustment step to induce the proper hydrate form and thereby avoiding inadvertent nucleation of undesired hydrate forms.

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Gossman, W.L. et al., “Three Hydrates of the Bisphosphonate Risedronate, Consisting of One Molecular and Two Ionic Structures”,Acta Crystallographica Section C. Crystal Structure Communication, 2003, pp. M33-M36, vol. 50, No. 2.
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