Process for controlled depolymerization of polysaccharides

Details Process for controlled depolymerization of polysaccharides Process for controlled depolymerization of polysaccharides

1987-11-19

1990-12-11

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 56, 536124, C08B 3710, C07H 100, C07H 300

Patent

active

049772503

ABSTRACT:
A process for controlled chemical depolymerization of naturally occurring linear polysaccharides, more specifically glycosaminoglycans. Depolymerized glycosaminoglycans, such as heparins which are obtained according to the process and pharmaceutical compositions which contain such depolymerized heparins. In the process, the polysaccharides are subjected to the action of atomic oxygen which, preferably, is derived from hypochlorous acid.

REFERENCES:
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patent: 4446314 (1984-05-01), Jordan
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patent: 4727063 (1988-02-01), Naggi et al.
patent: 4745098 (1988-05-01), Michaeli
patent: 4745105 (1988-05-01), Griffin et al.
patent: 4745107 (1988-05-01), Foley et al.
patent: 4767463 (1988-08-01), Brode et al.
patent: 4816446 (1989-03-01), Feller et al.
Unit Processes in Organic Synthesis, P. H. Groggins, 1938, pp. 368 & 376.
The Merck Index, Merck & Co., Inc., Rahway, N.J., 1960, p. 946.

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