Process for constructing cDNA library, and novel polypeptide and

Details Process for constructing cDNA library, and novel polypeptide and Process for constructing cDNA library, and novel polypeptide and

1994-01-14

1996-06-11

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 435 694, 435 912, 435 914, 435 915, 435 9151, 435 9152, 435183, 4351723, 4353201, 536 231, 536 253, 935 78, 935 88, C12N 1500

Patent

active

055254861

ABSTRACT:
The present invention relates to (1) a process for constructing a cDNA library which has a selectivity for signal peptides, that makes it possible to efficiently find out an unknown and useful polypeptide and a high efficiency; and relates to (2) a novel polypeptide consisting of 89 amino acids (including a signal peptide) produced by a stroma cell line, which is useful as an agent for preventing or treating, for example, anemia, leukopenia or infections and the like, and DNAs encoding for said polypeptide.

REFERENCES:
patent: 5159062 (1992-10-01), Knapp et al.
Nucl. Acids Res., vol. 19, No. 25, Dec. 1991, IRL Press, Oxford, England, pp. 7097-7104, E. Hara et al, "Subtractive cDNA cloning using oligo(dT).sub.30 -latex and PCR: isolation of cDNA clones specific to undifferentiated human embryonal carcinoma cells".
Science, vol. 261, 30 Jul. 1993, AAAS, Washington, D.C. (US), pp. 600-603, K. Tashiro et al, "Signal sequence trap: A cloning strategy for secreted proteins and type I membrane proteins".
Proc. Natl. Acad. Sci., vol. 91, No. 6, 15 Mar. 1994, Natl. Acad. Sci., Washington, D.C. (US), pp. 2305-2309, T. Nagasawa et al, "Molecular cloning and structure of a pre-B-cell growth-stimulating factor".

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