Process for concentrating blood coagulation Factor XIII derived

Details Process for concentrating blood coagulation Factor XIII derived Process for concentrating blood coagulation Factor XIII derived

1979-11-02

1981-08-25

Cacciapaglia, Jr., Frank

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3548

Patent

active

042859336

ABSTRACT:
The invention relates to a process for concentrating blood coagulation Factor XIII (Fibrin stabilizing factor) which comprises removing a fraction precipitated at a pH of 6 to 9 in a concentration of 4 to 9% (W/V) of an alkylenoxide polymer or copolymer having a molecular weight of 2,000 to 20,000 from a crude globulin fraction obtained from human placentae by separating in albumin fraction therefrom, and then collecting the fraction precipitated in the concentration of 20 to 30% (W/V) of said polymer or copolymer, thereby obtaining easily said blood coagulation Factor XIII free from pyrogen in good yield.

REFERENCES:
patent: 3880989 (1975-04-01), Garcia
Pisano, Ann. N.Y. Acad. Sci., Zoz: 98 (1972).
McDonagh, 16th Int'l Cong. Hematol, Kyoto, (1976).
Mosher, J. Biol. Chem. 250:6614 (1975).

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