Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1982-04-29
1984-04-10
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
A01N 6302
Patent
active
044420919
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a process for combatting and/or preventing allergic diseases and more particularly those allergic diseases which are caused by house-dust mites.
For a long time allergic diseases were supposed to be caused by tiny vegetable pollens in the atmosphere. Later on it was supposed that these diseases could also be caused by the abundance of mould spores.
Although intensive research was carried out for many years, efficient means for combatting allergic diseases, particularly those actually caused by house-dust mites and more particularly those occurring in mattress-dust and the like did not become available up to now.
From Mykosen 20(3), 101-106 it is known that fungi belonging to the species of Aspergillus glaucus and Aspergillus restrictus play a role in the ecology of the house-dust mites and in the origination of the house dust allergen, while Mykosen 18(9), 385-392 discloses the results of a study of a presumed interaction between Tyrophagus putrescentiae and some fungi.
A presumed interaction of several fungi with Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei was also described, see for example Environ. Entomol. 2(1), 142-145 (1973), Oecologia (Berl) 33(3), 351-360 (1978) and Oecologia (Berl) 36(1), 81-92, (1978).
Furthermore, it is known to destroy other types of mites which are found in agricultural products or to inhibit their development by applying mixtures of fungicides and/or pesticides with a variety of molecular structures, see for example Japanese patent applications 79/101.426 and 77/076.428.
Several methods have been tried in order to influence the presumed relationship between the growth of fungi in dry domestic dust on the one hand and the occurrence and growth of house-dust mites on the other hand. For example, in J. Med. Entomol. 8, 748 (1971) the use of the fungicide Nipagin.RTM. (methyl p-hydroxybenzoate) is described in the control of house-dust mites and microorganisms, but only under laboratory conditions. However, these proposed methods did not give rise to an adequate combatting method for the aforementioned allergic diseases up to now, because the agents used were not sufficiently active or showed an unacceptable high toxicity and/or caused allergic reactions.
Surprisingly, as a result of extensive research and experimentation a process was now found for an adequate combatting method of allergic diseases, which are mainly caused by house-dust mites and more particularly by species of Dermathophagoides pteronyssinus and Dermathophagoides farinae.
It has been found that these species live in combination and interaction with certain specific fungi, which are naturally present in house-dust and more particularly in mattress-dust. The most important fungi in this connection were found to be Aspergillus penicilloides, Aspergillus glaucus and Aspergillus restrictus. Of these, Aspergillus penicilloides appeared the most important factor for the growth, survival and reproduction of house-dust mites.
It has now been found that the use of a particular fungicide, natamycin, caused an effective inhibitory effect on the growth, development and reproduction of house-dust mites, which resulted in an important decrease of certain allergic affections.
Thus, the present invention relates to a process for combatting and/or preventing allergic diseases which are caused by house-dust mites, characterised in that said mites or places or areas, which are afflicted or may be afflicted by said mites, are treated with an effective amount of natamycin.
The invention relates also to a composition for destroying house-dust mites and inhibiting the growth of populations of house-dust mites, particularly species of Dermatophagoides pteronyssinus and Dermatophagoides farinae, which comprises an effective amount of natamycin in conjunction with a vehiculum or carrier.
The invention relates further to mattresses, bedding and the like, which are treated with of natamycin for destroying house-dust mites and inhibiting growth of populations of such mites.
Usuall
REFERENCES:
patent: 3892850 (1975-07-01), Struyk et al.
Bronswijk et al.; vol. 77, 15, 518p (1972).
Leysen et al., vol. 83, 54, 531f (1975).
"Rote Liste" (1979) #20020B and #20021B
de Saint Georges-Gridelet Daniele
Lebrun Philippe
Gist-Brocades N.V.
Robinson Allen J.
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