Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing a...
Patent
1980-01-18
1981-11-17
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing a...
435911, C12P 3306
Patent
active
043012469
ABSTRACT:
A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.
REFERENCES:
patent: 3047470 (1962-07-01), Pruess et al.
patent: 3539449 (1970-11-01), Marx et al.
patent: 4220716 (1980-09-01), Fujiwara et al.
Despreaux Carl
Narwid Thomas A.
Palleroni Norberto J.
Uskokovic Milan R.
Callwood James H.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
Tanenholtz Alvin E.
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