Process for cephalosporanic acid derivatives and intermediate th

Details Process for cephalosporanic acid derivatives and intermediate th Process for cephalosporanic acid derivatives and intermediate th

1983-06-20

1985-03-05

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

548170, C07D41712, C07D50104

Patent

active

045032211

ABSTRACT:
The process for preparing cephalosporanic acid derivatives ##STR1## and salts thereof with bases as well as solvates thereof, comprising reacting a compound of the formula II: ##STR2## wherein R.sub.3 represents hydrogen or an amino protecting group and R.sub.2 represents hydrogen, an easily removable ester group or other carboxyl protecting group, with a compound of formula IIIa, ##STR3## wherein R.sub.1 represents hydrogen, an easily removable ester group or other carboxyl protecting group, and R.sub.4 is a 2-benzothiazol group and salts thereof with bases, and if required removing any ester group or protecting group.

REFERENCES:
patent: 2090242 (1937-08-01), Teppema et al.
patent: 4024137 (1977-05-01), Cook et al.
patent: 4314059 (1982-02-01), Shibuya et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4351947 (1982-09-01), Shibuya et al.
patent: 4456754 (1984-06-01), Murakami et al.

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