Process for C-methylation of 2-methylbutyrates

Details Process for C-methylation of 2-methylbutyrates Process for C-methylation of 2-methylbutyrates

1985-05-23

1986-04-15

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560256, C07D30910

Patent

active

045829152

ABSTRACT:
Mevinolin, compactin and dihydro- and tetrahydro derivatives thereof are converted to more active HMG-CoA reductase inhibitors by C-methylation of the natural 2(S)-methylbutyryloxy side chain to form a 2,2-dimethylbutyryloxy side chain.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4351844 (1982-09-01), Patchett et al.
patent: 4490546 (1984-12-01), Kuo
Herbert O. House, Modern Synthetic Reactions, 2nd Ed. (1972), pp. 1-3.
Kuo et al, JACS, 93:23 (1971) pp. 6321-6323.
Dubois et al, Bull. Soc. Chim. Fr. (1963), pp. 1491-1496.
Ewing et al, J. Org. Chem., 40 (1975), pp. 2965-2966.
W. Carruthers, Some Modern Methods of Organic Synthesis, 2nd Ed., p. 2.
R. G. Pearson et al, JACS, 75 (1953), pp. 2439-2443.
Rathke et al, JACS, 93:9 (1971), pp. 2318-2320.
John C. Stowell, Carbanions in Organic Synthesis (1979), pp. 157-158.
Pfeffer et al, J. Org. Chem., vol. 37:3 (1972), pp. 451-458.
J. Herrmann et al, Tetrahedron Letters, No. 26 (1973), pp. 2429-2432.
Heathcock et al, J. Org. Chem., 45 (6) (1980), pp. 1066-1081.
Cregge et al, Tetrahedron Letters, No. 26 (1973), pp. 2425-2428.
M. Larcheveque et al, CA, 84:179576b.
Warner et al, J. Org. Chem. (1982), vol. 47, pp. 893-895.
G. Frater, Tetrahedron Letters (1981) 22(5), pp. 425-428.
D. Seebach et al, Helv. Chim. Acta, 63(1) (1980), pp. 197-200.
P. L. Creger, JACS, 89(10) (1967), pp. 2500-2501.

Affiliated with

Also associated with

Rating

Process for C-methylation of 2-methylbutyrates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for C-methylation of 2-methylbutyrates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for C-methylation of 2-methylbutyrates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1439665