Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Patent
1991-10-15
1994-08-02
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
4352522, 4352521, 435244, C12N 120, C12N 138, C12P 1302
Patent
active
053345193
ABSTRACT:
In a process for biological production of an amide wherein a nitrile is hydrated into a corresponding amide by the action of a nitrile hydratase originated in a microorganism, the improvement which comprises the use of nitrile hydratase which is obtained by culturing a microorganism of the species Rhodococcus rhodochrous in the presence of a cobalt ion.
Aromatic nitriles such as a cyanopyridine as well as aliphatic nitrile such as acrylonitrile are hydrated into the corresponding amides.
REFERENCES:
patent: 4629700 (1986-12-01), Prevatt
patent: 5135858 (1992-08-01), Yamada
Demain et al., "Industrial Microbiology and Technology", p. 103, 1986, ASM.
Harper, D. B., Biochem J., 1977, vol. 165, pp. 309-319.
Goodfellow et al. "The Biology of Actinomycetes", 1984, Academic Press, pp. 91-94.
Nagasawa et al. Nitrile Hydratase-catalyzed Production of Nicotinamide from 3-Cyanopyridine in Rhodococcus rhodchrous J1, Applied and Environmental Microbiology, vol. 54, No. 7 pp. 1766-1769, @Jul. 1988, Department of Agricultural Chemistry, Kyoto University, Kitashirakawa, Oiwake-Cho, Sakyo-ku, Kyoto 606, Japan.
Nagasawa et al., Occurrence of a Cobalt-Induced and Cobalt-Containing Nitrile Hydratase in Rhodococcus rhodochrous J1, Biochemical and Biophysical Research Communications, vol. 155, pp. 1008-1016, Academic Press, @Sep. 15, 1988. Department of Agricultural Chemistry, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606, Japan.
Collins et al., The Utilization of Nitriles by Nocardia rhodochrous, Journal of General Microbiology, pp. 711-718, @ 1983, (Printed in Great Britain), Biological Laboratory, University of Kent, Canterbury, Kent CT2 7NJ U.K.
Mayger et al., Nitrile Hydratase-Catalyzed Production of Isonicotinamide, Picolinamide and Pyrazinamide from 4-Cyanopyridine, 2-Cyanopyridine and Cyanopyrazine in Rhodococcus thodochrous J-1, Journal of Biotechnology, 8, @ 1988, Department of Agricultural Chemistry, Kyoto University, Kitashirakawa Sakyo-ku, Kyoto 606, Japan.
Asano, et al., Aliphatic Nitrile Hydratase from Arthrobacter Sp. J-1 Purification and Characterization, Agric. Biol. Chem., 46, pp. 1165-1174, 1982, Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan.
Nagasawa Toru
Yamada Hideaki
Burns Robert E.
Lobato Emmanuel J.
Marx Irene
Nitto Kagaku Kogyo Kabushiki Kaisha
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