Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i

Details Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i

1991-07-22

1992-04-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07D205085, C07D48704

Patent

active

051069687

ABSTRACT:
1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C.sub.2 -C.sub.10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-substituted alkoxy)-2-oxo-4-azetidinyl)-.beta.-ketobutyric acid and an ester of a 5-(1-alkoxy- or 1-substituted alkoxy-2-oxo-4-azetidinyl)-.alpha.-diazo-.beta.-ketovaleric acid respectively. The process is carried out in an inert organic solvent at a temperature between about 15.degree. C. and about 85.degree. C. The 1-carba bicyclic .beta.-lactams are intermediates for preparing antibiotics.

REFERENCES:
Williams, Tet. Letters 31(13) 1807-10 (1990).

Affiliated with

Also associated with

Rating

Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for bicyclic .beta.-lactams diazo-.beta.-keto-butyrate-i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1587683