Process for asymmetric total synthesis of camptothecin analogues

Details Process for asymmetric total synthesis of camptothecin analogues Process for asymmetric total synthesis of camptothecin analogues

1993-06-10

1995-04-11

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49122

Patent

active

054059631

ABSTRACT:
The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue. ##STR1##

REFERENCES:
Meyers et al., J. Org. Chem., 38(11), pp. 1974-1982 (1974).
Krohn et al., Liebigs Ann. Chem. pp. 949-953 (1988).

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