Process for assaying cellular immunity

Details Process for assaying cellular immunity Process for assaying cellular immunity

1985-03-06

1986-06-17

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, C12Q 170

Patent

active

045956537

ABSTRACT:
The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.

REFERENCES:
Hyde, J. et al., Biochem. 17, 1251 (1978).
Isaacs, S. et al., Biochem. 16, 1058 (1977).
Musajo, L. et al., Experentia 21, 22 (1965).
Musajo, L. et al., Photochem. Photobiol. 6, 711 (1967).
Musajo, L. et al., Photochem. Photobiol. 6, 927 (1967).
Nakashima, K. et al., J. Bio. Chem. 253, 8680, (1978).
Cole, R. S., Biochim. Biophys. Acta. 217, 30 (1979).
Colombo, G. et al., Prog. Biochem. Pharmacol. 1, 392, (1965).
Hallick, L. et al., J. Virol. 27, 127, (1978).
Hanson, C. et al., J. Gen. Virol. 40, 345 (1978).
Hearst, J. et al., Nucleic Acids Res. 4, 1339, (1977).
Hochkeppel, H-K, et al., Biochem. 18, 2905, (1979).
Nakashima, K. et al., J. Virol. 32, 838, (1979).
Scott, B. et al., Mut. Res. 39, 29 (1976).
Shen, C-K, et al., Proc. Nat. Acad. Sci. USA 73, 2649, (1976).
Shen, C-K, et al., J. Mol. Biol. 116, 661, (1977).
Song, P-S, et al., Photochem. Photobiol. 29, 1177 (1979).
Chem. Abstracts 93, 142760s.
Chem. Abstracts 88, 182868m.

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