Process for aromatic bromination

Details Process for aromatic bromination Process for aromatic bromination

1992-07-08

1993-09-28

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

122493, 122480, 560 45, 560 47, 560 65, 560 83, C07C 6500

Patent

active

052488179

ABSTRACT:
A novel procedure for bromination of aromatic moieties utilizes N-bromosuccinimide or dibromodimethylhydantoin in an aqueous alkali medium. The bromination procedure is employed for the preparation of an intermediate used in the preparation of remoxipride, an antipsychotic compound.

REFERENCES:
patent: 4232037 (1980-11-01), Florvall
patent: 4789683 (1988-12-01), Florvall et al.
CA 77(5):34088g 1972.
CA 100 (17):138334b 1984.
CA 114 (1):6013a 1989.
J. S. Pizey, N-Bromosuccinimide, Synthetic Reagents, 2, 1 (John Wiley New York, 1974).
L. Florvall and Sven-Ove Ogren, J. Med. Chem., 25, 1280 (1982).
V. Oakes et al., J. Chem. Soc., 4678 (1962).

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