Process for aqueous granulation of clarithromycin

Details Process for aqueous granulation of clarithromycin Process for aqueous granulation of clarithromycin

1996-10-09

1999-07-06

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514952, 514974, 5147726, A61K 916, A61K 4732

Patent

active

059194898

ABSTRACT:
The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

REFERENCES:
patent: 4608278 (1986-08-01), Frank et al.
patent: 4808411 (1989-02-01), Fu Lu et al.
Fu Lu, M. F., et al., "A Polymer Carrier System For Taste Making Of Macrolide Antibiotics", Research Article, pp. 706-712.

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