Process for antibody combining site-catalyzed epoxide formation

Details Process for antibody combining site-catalyzed epoxide formation Process for antibody combining site-catalyzed epoxide formation

1994-01-24

1995-07-04

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4351885, C12P 1702, C12N 900

Patent

active

054299411

ABSTRACT:
A process is disclosed by which a 1-benzyl-1-hydrocarbyl alkene substrate is catalytically converted to an epoxide. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to an N-benzyl-N-hydrocarbylpiperidinium compound that is an analog to the substrate. The chemical reaction is carried out in an aqueous medium using a peroxycarboximic acid as the oxidant.

REFERENCES:
Reymond, Jr., et al, (1992) J. Am. Chem. Soc. 114, 2257-2258.
Reymond, Jr., et. al. (1994) Angew. Chem, Int. Ed. Engl. 33(4), 475-477.
Sinha, S. C, et. al, (1993) Proc. Natl. Acad. Sci, USA. 90, 11910-11913.
Reymond, J. L, et. al. (1991) Angew. Chem. Ed. Engl. 30 (12), 1711-1713.
Reymond, J. L., et. al. (1993) J. Am. Chem. Soc. 115, 3907-3917.
Sinha, S. C., et al. (1993) J. Am. Chem. Soc. 115, 4893-4894.

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