Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-07-12
1993-06-29
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2853, 536 2761, 536 276, 536 2781, C07H 100
Patent
active
052236080
ABSTRACT:
The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.
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Encyclopedia of Polymer Science and Engineering, Second Ed., H. F. Mark et al., eds., John Wiley and Sons, New York, vol. 8, p. 346 (1987).
Chou Ta-Sen
Heath Perry C.
Brown Johnnie R.
Eli Lilly and Company
Taylor Douglas J.
Whitaker Leroy
Wilson James O.
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