Process for and intermediates of 2',2'-difluoronucleosides

Details Process for and intermediates of 2',2'-difluoronucleosides Process for and intermediates of 2',2'-difluoronucleosides

1989-12-04

1990-10-23

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549318, 536 23, 536 24, 536 26, C07D30732

Patent

active

049653741

ABSTRACT:
The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.

REFERENCES:
patent: 2359096 (1944-09-01), Elderfield
patent: 2607800 (1952-08-01), Arundale
patent: 4526988 (1985-07-01), Hertel et al.
patent: 4837344 (1989-06-01), Miyaji et al.
patent: 4855446 (1989-08-01), Duke et al.
Dowex::ION Exchange, The Dow Chemical Company, Midland, Mich., p. 71, 1959.
Encyclopedia of Polymer Science and Engineering, Second Edition, H. F. Mark et al., eds., John Wiley and Sons, New York, 1987, vol. 8, p. 346.

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