Process for altering the host range or increasing the toxicity o

Details Process for altering the host range or increasing the toxicity o Process for altering the host range or increasing the toxicity o

1997-05-13

2000-07-18

Smith, Lynette R. F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435440, 435468, 435471, C12N 1532, C12N 1562, C12N 1570, C12N 1582

Patent

active

060909315

ABSTRACT:
The invention concerns an in vitro process for altering the insect host range (spectrum) or increasing the toxicity of lepidopteran active B.t. crystal protein toxins. The process comprises recombining in vitro the variable region(s) (non-homologous) of two or more genes encoding lepidopteran active B.t. crystal protein toxins. Specifically exemplified is the recombining of the variable regions of two genes obtained from well-known strains of Bacillus thuringiensis var. kurstaki. The resulting products are chimeric toxins which are shown to have an expanded and/or amplified lepidopteran insect host range as compared to the parent toxins.

REFERENCES:
patent: 4448885 (1984-05-01), Schnepf et al.
patent: 4467036 (1984-08-01), Schnepf et al.
Schnepf He, et al. Bacillus thuringiensis toxins: regulation, activities and structural diversity. Curr. Opinions Biotech. 6: 305-312, 1995.
Schnepf, H. Ernest and H.R. Whiteley (1981) "Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli", Proc. Natl. Acad. Sci. 78(5):2893-2897.

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