Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Viscosity
Reexamination Certificate
2001-07-02
2002-11-12
Williams, Hezron (Department: 2856)
Measuring and testing
Liquid analysis or analysis of the suspension of solids in a...
Viscosity
C073S064550, C073S054020, C073S054040, C073S064560
Reexamination Certificate
active
06477891
ABSTRACT:
CROSS-REFERENCE TO RELATED APPLICATIONS
DE 1 95 01 159 A1
DE 44 40 095 A1
DE 42 03 466 A1
STATEMENT REGARDING FEDERALLY SPORNSORED RESEARCH OR DEVELOPMENT
Not applicable
REFERENCE TO A MICROFICHE APPENDIX
Not applicable
BACKGROUND OF THE INVENTION
The invention relates to the technical field of affinity assays and affinity sensors in general and of the viscosimetric principle of determination of affinity bonds in special.
BRIEF SUMMARY OF THE INVENTION
The invention makes available a process of affinity viscosimetry and a viscosimetric affinity sensor suitable for measuring the concentration of low-molecular weight affinity ligands, e.g. sugars. The general idea of the invention consists in the measurement of the analyte-sensitive flow resistance of the sensitive liquid at a high shear rate. The shear rate at viscosity measurement is at least twice the shear rate at the dialysis process. The temporal and/or spatial separation of the dialysis process from the rheological analysis enables several advantages, especially miniaturization of the implantable part of the sensor and compensation of temperature effects.
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Ballerstadt, R. et al. “Viscosimetric Affinity Assay”,Analytical Biochemistry234, vol. 0040, pp. 1-8 (1996).
Ballerstadt, R. et al. “Suitability of aqueous dispersions of dextran and Concanavalin A for glucose sensing in different variants of the affinity sensor”,Biosensors&Bioelectronics9 pp. 557-567 (1994).
Beyer Uwe
Ehwald Karl-Ernst
Ehwald Rudolf
Thomas Andreas
Disetronic Licensing AG
Wiggins David J.
Williams Hezron
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